Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication

Polymerase Dynamics at the Eukaryotic DNA Replication

This review discusses recent insights in the roles of DNA polymerases (Pol) and in eukaryotic DNA replication. A growing body of evidence specifies Pol as the leading strand DNA polymerase and Pol as the lagging strand polymerase during undisturbed DNA replication. New evidence supporting this model comes from the use of polymerase mutants that show an asymmetric mutator phenotype for certain m...

Eukaryotic DNA polymerase ζ.

This review focuses on eukaryotic DNA polymerase ζ (Pol ζ), the enzyme responsible for the bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also responsible for a large portion of mutagenesis during normal cell growth, in response to spontaneous damage or to certain DNA structures and other blocks that stall DNA replication forks. Novel insights in mutagenesis have be...

Role of yeast DNA polymerase epsilon during DNA replication

Polymerase dynamics at the eukaryotic DNA replication fork.

This review discusses recent insights in the roles of DNA polymerases (Pol) delta and epsilon in eukaryotic DNA replication. A growing body of evidence specifies Pol epsilon as the leading strand DNA polymerase and Pol delta as the lagging strand polymerase during undisturbed DNA replication. New evidence supporting this model comes from the use of polymerase mutants that show an asymmetric mut...

Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication.

Human DNA polymerase eta (Pol eta) modulates susceptibility to skin cancer by promoting translesion DNA synthesis (TLS) past sunlight-induced cyclobutane pyrimidine dimers. Despite its well-established role in TLS synthesis, the role of Pol eta in maintaining genome stability in the absence of external DNA damage has not been well explored. We show here that short hairpin RNA-mediated depletion...